A major cause of pancreatic cancer

For a long time, cancer researchers the use of epidemiological and laboratory research methods, analysis of the age, sex, race, heredity, diet, nutrition, occupation, coffee and tobacco, and other factors, after extensive research that the majority of pancreatic cancer by the caused by repetitive action of multiple factors. High-protein diet may be related to the pathogenesis of pancreatic cancer, which is in animal experiments has been confirmed. Mice fed with soybean meal, the secretion of gastrin and cholecystokinin can stimulate pancreatic tissue proliferation and nodule formation. Epidemiological investigation is also evidence to support this view, such as smoking, drinking coffee and drinking it can cause an increase in gastrin secretion, which led to the role of pancreatic cancer remains to be further demonstrated.

In recent years, people are watching with interest of chronic pancreatitis and pancreatic cancer relationship. 1985 Nogueria in 136 cases of chronic calcifying pancreatitis and found that 2.2% of cases associated with pancreatic cancer, this ratio than the general population the incidence of pancreatic cancer nearly a hundred times higher. Of pancreatic cancer in a group of autopsy reports, not involving pancreatic cancer organizations were as high as 41% of ductal hyperplasia, ductal hyperplasia may be carcinogenic or endocrine imbalance in the role of factors caused the accident. Some people use large vole experimental object, cellophane tape surrounding the pancreatic head, in 5 days after operation will see the pancreatic head main pancreatic duct epithelial cell proliferation, goblet cell metaplasia, thus the surrounding fibrosis and pancreatic duct catheter partial obstruction, and proved pancreatic duct obstruction, retention, and pancreatic duct epithelial hyperplasia and the occurrence of pancreatic cancer has a close relationship.